DICER1

From Wikipedia, the free encyclopedia

Dicer1, Dcr-1 homolog (Drosophila)

Identifiers

DICER1; Dicer; HERNA; KIAA0928

External IDs

OMIM: 606241 MGI: 2177178 HomoloGene: 13251

Gene ontology
Molecular Function:	• nucleotide binding • double-stranded RNA binding • endonuclease activity • ribonuclease III activity • protein binding • ATP binding • ATP-dependent helicase activity • hydrolase activity
Cellular Component:	• intracellular
Biological Process:	• RNA processing • stem cell maintenance • lung development • RNA interference, production of siRNA • RNA interference, targeting of mRNA for destruction • embryonic hindlimb morphogenesis • miRNA-mediated gene silencing, production of miRNAs • branching morphogenesis of a tube

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_030621 (mRNA)
NP_085124 (protein)

NM_148948 (mRNA)
NP_683750 (protein)

Location

n/a

Chr 12: 105.09 - 105.15 Mb

Pubmed search

[1]

[2]

Dicer1, Dcr-1 homolog (Drosophila), also known as DICER1, is a human gene.^[1] It is present in many organisms, as Dicer.

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: DICER1 Dicer1, Dcr-1 homolog (Drosophila).

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Provost P, Samuelsson B, Rådmark O (1999). "Interaction of 5-lipoxygenase with cellular proteins.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881–5. PMID 10051563.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032.
Suk K, Kim S, Kim YH, et al. (2000). "Identification of a novel human member of the DEAD box protein family.". Biochim. Biophys. Acta 1501 (1): 63–9. PMID 10727850.
Matsuda S, Ichigotani Y, Okuda T, et al. (2000). "Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase.". Biochim. Biophys. Acta 1490 (1-2): 163–9. PMID 10786632.
Tabara H, Yigit E, Siomi H, Mello CC (2002). "The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.". Cell 109 (7): 861–71. PMID 12110183.
Provost P, Dishart D, Doucet J, et al. (2002). "Ribonuclease activity and RNA binding of recombinant human Dicer.". EMBO J. 21 (21): 5864–74. PMID 12411504.
Zhang H, Kolb FA, Brondani V, et al. (2002). "Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP.". EMBO J. 21 (21): 5875–85. PMID 12411505.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Doi N, Zenno S, Ueda R, et al. (2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.". Curr. Biol. 13 (1): 41–6. PMID 12526743.
Kawasaki H, Taira K (2003). "Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells.". Nucleic Acids Res. 31 (2): 700–7. PMID 12527779.
Kawasaki H, Suyama E, Iyo M, Taira K (2003). "siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells.". Nucleic Acids Res. 31 (3): 981–7. PMID 12560494.
Sasaki T, Shiohama A, Minoshima S, Shimizu N (2004). "Identification of eight members of the Argonaute family in the human genome small star, filled.". Genomics 82 (3): 323–30. PMID 12906857.
Handa V, Saha T, Usdin K (2003). "The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer.". Nucleic Acids Res. 31 (21): 6243–8. PMID 14576312.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tahbaz N, Kolb FA, Zhang H, et al. (2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.". EMBO Rep. 5 (2): 189–94. doi:10.1038/sj.embor.7400070. PMID 14749716.
Zhang H, Kolb FA, Jaskiewicz L, et al. (2004). "Single processing center models for human Dicer and bacterial RNase III.". Cell 118 (1): 57–68. doi:10.1016/j.cell.2004.06.017. PMID 15242644.