Diaminopimelate epimerase

From Wikipedia, the free encyclopedia

In enzymology, a diaminopimelate epimerase (EC 5.1.1.7) is an enzyme that catalyzes the chemical reaction

LL-2,6-diaminoheptanedioate meso-diaminoheptanedioate

Hence, this enzyme has one substrate, LL-2,6-diaminoheptanedioate, and one product, meso-diaminoheptanedioate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is LL-2,6-diaminoheptanedioate 2-epimerase. This enzyme participates in lysine biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1BWZ, 1GQZ, 2GKE, and 2GKJ.

[edit] References

• IUBMB entry for 5.1.1.7
• BRENDA references for 5.1.1.7 (Recommended.)
• PubMed references for 5.1.1.7
• PubMed Central references for 5.1.1.7
• Google Scholar references for 5.1.1.7
• ANTIA M, HOARE DS, WORK E (1957). "The stereoisomers of alpha epsilon-diaminopimelic acid. III Properties and distribution of diaminopimelic acid racemase, an enzyme causing interconversion of the LL and meso isomers". Biochem. J. 65: 448–59. PMID 13412646. 

[edit] External links

The CAS registry number for this enzyme class is 9024-22-0.

• IUBMB entry for 5.1.1.7

• KEGG entry for 5.1.1.7

• BRENDA entry for 5.1.1.7

• NiceZyme view of 5.1.1.7

• EC2PDB: PDB structures for 5.1.1.7

• PRIAM entry for 5.1.1.7

• PUMA2 entry for 5.1.1.7

• IntEnz: Integrated Enzyme entry for 5.1.1.7

• MetaCyc entry for 5.1.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008837: diaminopimelate epimerase

• AMIGO entry for GO code 0008837: diaminopimelate epimerase