Diaminopimelate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a diaminopimelate decarboxylase (EC 4.1.1.20) is an enzyme that catalyzes the chemical reaction

meso-2,6-diaminoheptanedioate L-lysine + CO₂

Hence, this enzyme has one substrate, meso-2,6-diaminoheptanedioate, and two products, L-lysine and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming). Other names in common use include diaminopimelic acid decarboxylase, meso-diaminopimelate decarboxylase, DAP-decarboxylase, and meso-2,6-diaminoheptanedioate carboxy-lyase. This enzyme participates in lysine biosynthesis. It employs one cofactor, pyridoxal phosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1HKV, 1HKW, 1KNW, 1KO0, 1TUF, 1TWI, 2O0T, and 2P3E.

[edit] References

• IUBMB entry for 4.1.1.20
• BRENDA references for 4.1.1.20 (Recommended.)
• PubMed references for 4.1.1.20
• PubMed Central references for 4.1.1.20
• Google Scholar references for 4.1.1.20
• DENMAN RF, HOARE DS, WORK E (1955). "Diaminopimelic acid decarboxylase in pyridoxin-deficient Escherichia coli". Biochim. Biophys. Acta. 16: 442–3. PMID 14378182. 

[edit] External links

The CAS registry number for this enzyme class is 9024-75-3.

• IUBMB entry for 4.1.1.20

• KEGG entry for 4.1.1.20

• BRENDA entry for 4.1.1.20

• NiceZyme view of 4.1.1.20

• EC2PDB: PDB structures for 4.1.1.20

• PRIAM entry for 4.1.1.20

• PUMA2 entry for 4.1.1.20

• IntEnz: Integrated Enzyme entry for 4.1.1.20

• MetaCyc entry for 4.1.1.20

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008836: diaminopimelate decarboxylase

• AMIGO entry for GO code 0008836: diaminopimelate decarboxylase