Diaminobutyrate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a diaminobutyrate decarboxylase (EC 4.1.1.86) is an enzyme that catalyzes the chemical reaction

L-2,4-diaminobutanoate $\rightleftharpoons$ propane-1,3-diamine + CO₂

Hence, this enzyme has one substrate, L-2,4-diaminobutanoate, and two products, propane-1,3-diamine and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming). Other names in common use include DABA DC, L-2,4-diaminobutyrate decarboxylase, and L-2,4-diaminobutanoate carboxy-lyase.

[edit] References

IUBMB entry for 4.1.1.86
BRENDA references for 4.1.1.86 (Recommended.)
PubMed references for 4.1.1.86
PubMed Central references for 4.1.1.86
Google Scholar references for 4.1.1.86
Yamamoto S, Tsuzaki Y, Tougou K, Shinoda S (1992). "Purification and characterization of L-2,4-diaminobutyrate decarboxylase from Acinetobacter calcoaceticus". J. Gen. Microbiol. 138: 1461–5. PMID 1512577.
Ikai H, Yamamoto S (1994). "Cloning and expression in Escherichia coli of the gene encoding a novel L-2,4-diaminobutyrate decarboxylase of Acinetobacter baumannii". FEMS. Microbiol. Lett. 124: 225–8. PMID 7813892.
Ikai H, Yamamoto S (1997). "Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii". J. Bacteriol. 179: 5118–25. PMID 9260954.