DHX36

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DEAH (Asp-Glu-Ala-His) box polypeptide 36
Identifiers
Symbol(s) DHX36; DDX36; KIAA1488; MLEL1
External IDs MGI: 1919412 HomoloGene: 6356
Orthologs
Human Mouse
Entrez 170506 72162
Ensembl ENSG00000174953 ENSMUSG00000027770
Uniprot Q9H2U1 A0JLR3
Refseq NM_020865 (mRNA)
NP_065916 (protein)		 NM_028136 (mRNA)
NP_082412 (protein)
Location Chr 3: 155.48 - 155.52 Mb Chr 3: 62.56 - 62.59 Mb
Pubmed search [1] [2]

DEAH (Asp-Glu-Ala-His) box polypeptide 36, also known as DHX36, is a human gene.[1]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36.

[edit] Further reading

  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. PMID 10819331. 
  • Fu JJ, Li LY, Lu GX (2002). "Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily.". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (5): 655–61. PMID 12198572. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tran H, Schilling M, Wirbelauer C, et al. (2004). "Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU.". Mol. Cell 13 (1): 101–11. PMID 14731398. 
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Vaughn JP, Creacy SD, Routh ED, et al. (2006). "The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates.". J. Biol. Chem. 280 (46): 38117–20. doi:10.1074/jbc.C500348200. PMID 16150737. 
  • Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains.". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMID 16482509. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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