DHX15

From Wikipedia, the free encyclopedia

DEAH (Asp-Glu-Ala-His) box polypeptide 15

Identifiers

DHX15; DBP1; DDX15; HRH2; PRP43; PRPF43; PrPp43p

External IDs

OMIM: 603403 MGI: 1099786 HomoloGene: 1040

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA helicase activity • ATP binding • ATP-dependent helicase activity • hydrolase activity • nucleoside-triphosphatase activity
Cellular Component:	• nucleus • U12-dependent spliceosome
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001358 (mRNA)
NP_001349 (protein)

NM_001042620 (mRNA)
NP_001036085 (protein)

Location

Chr 4: 24.14 - 24.2 Mb

Chr 5: 52.44 - 52.48 Mb

Pubmed search

[1]

[2]

DEAH (Asp-Glu-Ala-His) box polypeptide 15, also known as DHX15, is a human gene.^[1]

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.^[1]

[edit] References

^ ^a ^b Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15.

[edit] Further reading

Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases.". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. PMID 9747670.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.". RNA 10 (6): 929–41. PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fouraux MA, Kolkman MJ, Van der Heijden A, et al. (2002). "The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase.". RNA 8 (11): 1428–43. PMID 12458796.
Imamura O, Sugawara M, Furuichi Y (1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family.". Biochem. Biophys. Res. Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.
Ono Y, Ohno M, Shimura Y (1994). "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.". Mol. Cell. Biol. 14 (11): 7611–20. PMID 7935475.