DGKQ

From Wikipedia, the free encyclopedia

Diacylglycerol kinase, theta 110kDa

Identifiers

DGKQ; DAGK; DAGK4; DAGK7

External IDs

OMIM: 601207 MGI: 102918 HomoloGene: 20352

Gene ontology
Molecular Function:	• diacylglycerol kinase activity • zinc ion binding • transferase activity • diacylglycerol binding • metal ion binding
Biological Process:	• protein kinase C activation • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001347 (mRNA)
NP_001338 (protein)

NM_199011 (mRNA)
NP_950176 (protein)

Location

Chr 4: 0.94 - 0.96 Mb

Chr 5: 108.89 - 108.9 Mb

Pubmed search

[1]

[2]

Diacylglycerol kinase, theta 110kDa, also known as DGKQ, is a human gene.^[1]

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.^[1]

[edit] References

^ ^a ^b Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa.

[edit] Further reading

Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase.". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. PMID 9438377.
Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMID 17664281.
van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189.
Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.". Exp. Cell Res. 287 (1): 143–54. PMID 12799190.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.". J. Biol. Chem. 274 (11): 6820–2. PMID 10066731.
Houssa B, Schaap D, van der Wal J, et al. (1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.". J. Biol. Chem. 272 (16): 10422–8. PMID 9099683.
Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases.". J. Biol. Chem. 271 (14): 8394–401. PMID 8626538.
Endele S, Zabel B, Winterpacht A (1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3.". Genomics 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.