DGKD

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Diacylglycerol kinase, delta 130kDa
PDB rendering based on 1r79.
Available structures: 1r79
Identifiers
Symbol(s) DGKD; DGKdelta; KIAA0145; dgkd-2
External IDs OMIM: 601826 HomoloGene: 45153
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8527 n/a
Ensembl ENSG00000077044 n/a
Uniprot Q16760 n/a
Refseq NM_003648 (mRNA)
NP_003639 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 2: 233.93 - 234.05 Mb n/a
Pubmed search [1] n/a

Diacylglycerol kinase, delta 130kDa, also known as DGKD, is a human gene.[1]

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa.

[edit] Further reading

  • Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280. 
  • Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases.". J. Biol. Chem. 271 (14): 8394–401. PMID 8626538. 
  • Bregoli L, Baldassare JJ, Raben DM (2001). "Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin.". J. Biol. Chem. 276 (26): 23288–95. doi:10.1074/jbc.M101501200. PMID 11309392. 
  • Nagaya H, Wada I, Jia YJ, Kanoh H (2002). "Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains.". Mol. Biol. Cell 13 (1): 302–16. doi:10.1091/mbc.01-05-0255. PMID 11809841. 
  • Imai S, Sakane F, Kanoh H (2002). "Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation.". J. Biol. Chem. 277 (38): 35323–32. doi:10.1074/jbc.M202035200. PMID 12084710. 
  • Sakane F, Imai S, Yamada K, et al. (2003). "Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions.". J. Biol. Chem. 277 (45): 43519–26. doi:10.1074/jbc.M206895200. PMID 12200442. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Murakami T, Sakane F, Imai S, et al. (2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta.". J. Biol. Chem. 278 (36): 34364–72. doi:10.1074/jbc.M301542200. PMID 12810723. 
  • Imai S, Kai M, Yamada K, et al. (2005). "The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain.". Biochem. J. 382 (Pt 3): 957–66. doi:10.1042/BJ20040681. PMID 15228384. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Leach NT, Sun Y, Michaud S, et al. (2007). "Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.". Am. J. Hum. Genet. 80 (4): 792–9. doi:10.1086/513019. PMID 17357084. 
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