DGKB

From Wikipedia, the free encyclopedia

Diacylglycerol kinase, beta 90kDa

Identifiers

DGKB; DAGK2; DGK; DGK-BETA; KIAA0718

External IDs

OMIM: 604070 MGI: 2442474 HomoloGene: 37875

Gene ontology
Molecular Function:	• diacylglycerol kinase activity • calcium ion binding • zinc ion binding • transferase activity • diacylglycerol binding
Cellular Component:	• plasma membrane
Biological Process:	• protein kinase C activation • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004080 (mRNA)
NP_004071 (protein)

NM_178681 (mRNA)
NP_848796 (protein)

Location

Chr 7: 14.15 - 14.85 Mb

Chr 12: 38.39 - 39.14 Mb

Pubmed search

[1]

[2]

Diacylglycerol kinase, beta 90kDa, also known as DGKB, is a human gene.^[1]

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Caricasole A, Bettini E, Sala C, et al. (2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties.". J. Biol. Chem. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Goto K, Kondo H (1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons.". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7598–602. PMID 7689223.