DGCR8 (gene)

From Wikipedia, the free encyclopedia

DiGeorge syndrome critical region gene 8

PDB rendering based on 1x47.

Available structures: 1x47

Identifiers

Symbol(s)

DGCR8; C22orf12; DGCRK6; Gy1

External IDs

OMIM: 609030 MGI: 2151114 HomoloGene: 11223

Gene ontology
Molecular Function:	• double-stranded RNA binding • protein binding
Cellular Component:	• intracellular • nucleus • cytoplasm
Biological Process:	• primary microRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022720 (mRNA)
NP_073557 (protein)

NM_033324 (mRNA)
NP_201581 (protein)

Location

Chr 22: 18.45 - 18.48 Mb

Chr 16: 18.17 - 18.2 Mb

Pubmed search

[1]

[2]

DiGeorge syndrome critical region gene 8, also known as DGCR8, is a human gene.^[1]

[edit] References

^ Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Shiohama A, Sasaki T, Noda S, et al. (2003). "Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region.". Biochem. Biophys. Res. Commun. 304 (1): 184–90. PMID 12705904.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Gregory RI, Yan KP, Amuthan G, et al. (2004). "The Microprocessor complex mediates the genesis of microRNAs.". Nature 432 (7014): 235–40. doi:10.1038/nature03120. PMID 15531877.
Han J, Lee Y, Yeom KH, et al. (2005). "The Drosha-DGCR8 complex in primary microRNA processing.". Genes Dev. 18 (24): 3016–27. doi:10.1101/gad.1262504. PMID 15574589.
Landthaler M, Yalcin A, Tuschl T (2005). "The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.". Curr. Biol. 14 (23): 2162–7. doi:10.1016/j.cub.2004.11.001. PMID 15589161.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Han J, Lee Y, Yeom KH, et al. (2006). "Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.". Cell 125 (5): 887–901. doi:10.1016/j.cell.2006.03.043. PMID 16751099.
Faller M, Matsunaga M, Yin S, et al. (2007). "Heme is involved in microRNA processing.". Nat. Struct. Mol. Biol. 14 (1): 23–9. doi:10.1038/nsmb1182. PMID 17159994.
Sohn SY, Bae WJ, Kim JJ, et al. (2007). "Crystal structure of human DGCR8 core.". Nat. Struct. Mol. Biol. 14 (9): 847–53. doi:10.1038/nsmb1294. PMID 17704815.