Talk:Dextromethorphan

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Good article Dextromethorphan was a nominee for good article, but did not meet the good article criteria at the time. There are suggestions below for improving the article. Once these issues have been addressed, the article can be renominated. Editors may also seek a reassessment of the decision if they believe there was a mistake.
July 30, 2007 Good article nominee Not listed

Contents

[edit] Proposed split of Recreational use section to new article

Proposing split of "Recreational use" section to new article. This is a large and controversial issue that is a highly notable topic unto itself. Section has grown too large for, and beyond the relevance of, this article. Note: A separate article on Recreational use once existed (see here), but was merged into this article (on 10 Feb 2007, see AfD here). Equazcion •✗/C • 23:55, 27 December 2007 (UTC)

  • Yes, there's no doubt - it's rising in popularity and it's worth having an entire article. --Soonlaypale (talk) 21:27, 24 December 2007 (UTC)
  • 100% yes, though maybe might be seen as a pro-drug article by some --PA1412 (talk) 20:30, 6 March 2008 (UTC)

[edit] Chemistry

Much of the information in the Chemistry section of this article is either incorrect or problematic.

  • Dextromethorphan is not the methyl ester of anthing; it is a methyl ether.
  • It seems to me that levorphanol is levorotatory by definition, so the use of "d-levorphanol" is confusing at best, and probably incorrect. In any case, it's the L- stereoisomer, not the D- one, that's the narcotic analgesic. I suspect that much of this was copied inaccurately from this NIH page, which is itself somewhat confusingly worded.
  • The data on solubilities, appearance, and specific rotation seem a little bit problematic to me simply because no sources are given for any of them, and because it is sometimes unclear whether they refer to dextromethorphan as the free base or as the hydrobromide salt, but I'll leave it all in there more or less as is for now.
  • Finally, I saw above that someone requested synthesis information in the Chemistry section, and I am working on getting together some sources on that topic, which I plan on using to add a synthesis subsection in the future.

In any case, just letting everyone know that I am going to try to fix up that section. If anyone has a problem with the way I did it, by all means make your thoughts known. --SilenceIsPoetry (talk) 09:36, 29 December 2007 (UTC)

Guh?
Your scrutiny is appreciated, even if I don't understand exactly what you're saying, which is probably why the Chemistry section is in the state it's in as I've been generally leaving it alone -- it's a bit beyond me. So I appreciate having someone paying attention who knows this stuff. Thanks for any help you can provide there! Equazcion •✗/C • 11:37, 29 December 2007 (UTC)

[edit] Pharmacokinetics: DXM is active by itself

The article currently says:

"Dextromethorphan is rapidly absorbed from the gastrointestinal tract and converted into an active metabolite within 15 to 60 minutes of ingestion"

that is somehow confusing, because someone reading it may think that DXM is a complete pro-drug which needs to be converted to its metabolite in order to have an effect, it is wrong as DXM itself is active. This fact is even mentioned in "Clinical pharmacology" section but I think every section should be correct and clear.

Any ideas? Arman4 (talk) 18:41, 16 January 2008 (UTC)

Your completely right, Dextrorphan is apparently responsible for the stoning body high, while DXM is responsible for the mental effects. Try this by taking a small dose (2nd plat) and allowing yourself to get halfway in comeup, then take a higher dose of DXM, you'll notice a strong mental effect as the amount of Dxm to Do is increased (Dxm:Do). --68.45.219.63 (talk) 18:26, 6 March 2008 (UTC)
NMDA receptor antagonism is responsible for the mental effect, and dextrorphan is the more potent NMDA receptor antagonist, so dextrorphan is more responsible for the mental effect. But the original poster is correct that DXM itself is also active, especially as an antitussive, for which it is the more potent agent. Equazcion •✗/C • 18:30, 6 Mar 2008 (UTC)
Hmmm, thanks for the information Equazcion, I have read from various people the explanation I used. I assume they were wrong then. --68.45.219.63 (talk) 18:58, 6 March 2008 (UTC)

[edit] prevents ejaculation?

whenever i take dayquil with this stuff, or tylenol cough etc, i cannot ejaculate for about 4-5 days. i was wondering if anyone has read this anywhere about dxm, and if so could add it to the article. thank you -stuck with a boner 96.227.101.251 (talk) 17:11, 21 January 2008 (UTC)

Ha. Equazcion •✗/C • 17:16, 21 Jan 2008 (UTC)
  • This is a common side effect of DXM, inability to achive orgasm. It will come back after the DXM's active time is over --71.126.110.245 (talk) 04:50, 22 January 2008 (UTC)

[edit] Alleged use in drug dependency

I have removed this para from under the Additional Use section of the article. A reference to a patent application is not sufficient citation and this particular application is unproven Plutonium27 (talk) 02:14, 29 January 2008 (UTC)


[edit] Dextromethorphan Hbr versus Polix

Good edit on under the effects section regarding poli and Hbr, I added this but I am sure I explained it pretty bad. --68.45.219.63 (talk) 18:37, 6 March 2008 (UTC)

Thanks :) Equazcion •✗/C • 02:34, 7 Mar 2008 (UTC)

[edit] Should "abuse" be mentioned as "recreational use"?

The term abuse just sounds like a negative term and something that a anti-drug company would say in all of their stories. --PA1412 (talk) 20:37, 6 March 2008 (UTC)

The term "abuse", when used to describe the self-administration of a drug, is defined as using it in a manner not in accordance with medical or label recommendations. People who take more cough medicine than they're supposed to according to the label in order to achieve a high are by definition abusing the drug. It isn't necessarily a negative term, though it may sound that way to some people due to its other uses in other contexts. Equazcion •✗/C • 00:59, 7 Mar 2008 (UTC)
Okay, I usually see it as a negative term, perhaps it isn't, but thats what I would commonly hear in articles regarding DXM. --PA1412 (talk) 02:31, 7 March 2008 (UTC)

[edit] Mention...

Perhaps it should be mentioned the physical risk under Risks associated with abuse, such as falling and similar. --71.126.120.40 (talk) 00:21, 19 March 2008 (UTC)

[edit] Once again

Recreational use and medical use of dextromethorphan should be split into two separate sections. The rec section is becoming far too large for relevance to anything to do with the medical uses. It is a noteworthy topic of recent media attention and debate. --C6541 (talk) 21:17, 25 March 2008 (UTC)

Done. Equazcion •✗/C • 22:09, 25 Mar 2008 (UTC)

[edit] antitussive effect??

Just recently I read a debate in a medical journal on whether or not Dextromethorphan cough medicine is relevant at for treating cough. The MD's were pondering on this because of the abuse potential. So I was wondering whether there are any experimental double-blinded placebo controled experiments on the supposed antitussive effects? Couldn't find any. 80.221.34.239 (talk) 05:23, 9 May 2008 (UTC)

I find it unlikely my self that dextromethorphan is reliable in controlling coughs, it affects NMDA, Sigma 1 and 2, serotonin and nicotinic receptors which have nothing to do with coughs as far as I know C6541 (talk) 06:58, 10 May 2008 (UTC)