DERL2

From Wikipedia, the free encyclopedia

Der1-like domain family, member 2

Identifiers

DERL2; CGI-101; F-LAN-1; F-LANa; FLANa

External IDs

OMIM: 610304 MGI: 2151483 HomoloGene: 9356

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane • integral to endoplasmic reticulum membrane
Biological Process:	• positive regulation of cell proliferation • positive regulation of cell growth • ER-associated protein catabolic process • unfolded protein response • retrograde protein transport, ER to cytosol

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016041 (mRNA)
NP_057125 (protein)

NM_033562 (mRNA)
NP_291040 (protein)

Location

Chr 17: 5.32 - 5.33 Mb

Chr 11: 70.82 - 70.84 Mb

Pubmed search

[1]

[2]

Der1-like domain family, member 2, also known as DERL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: DERL2 Der1-like domain family, member 2.

[edit] Further reading

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093.
Ying H, Yu Y, Xu Y (2001). "Cloning and characterization of F-LANa, upregulated in human liver cancer.". Biochem. Biophys. Res. Commun. 286 (2): 394-400. doi:10.1006/bbrc.2001.5390. PMID 11500051.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lilley BN, Ploegh HL (2004). "A membrane protein required for dislocation of misfolded proteins from the ER.". Nature 429 (6994): 834-40. doi:10.1038/nature02592. PMID 15215855.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lilley BN, Ploegh HL (2006). "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14296-301. doi:10.1073/pnas.0505014102. PMID 16186509.
Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.". J. Cell Biol. 172 (3): 383-93. doi:10.1083/jcb.200507057. PMID 16449189.
Rhee S, Grinnell F (2006). "P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts.". J. Cell Biol. 172 (3): 423-32. doi:10.1083/jcb.200505175. PMID 16449192.
Maas C, Tagnaouti N, Loebrich S, et al. (2006). "Neuronal cotransport of glycine receptor and the scaffold protein gephyrin.". J. Cell Biol. 172 (3): 441-51. doi:10.1083/jcb.200506066. PMID 16449194.
Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL (2006). "Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection.". J. Virol. 80 (17): 8739-44. doi:10.1128/JVI.00791-06. PMID 16912321.