Dephospho-CoA kinase

From Wikipedia, the free encyclopedia

In enzymology, a dephospho-CoA kinase (EC 2.7.1.24) is an enzyme that catalyzes the chemical reaction

ATP + dephospho-CoA $\rightleftharpoons$ ADP + CoA

Thus, the two substrates of this enzyme are ATP and dephospho-CoA, whereas its two products are ADP and CoA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:dephospho-CoA 3'-phosphotransferase. Other names in common use include dephosphocoenzyme A kinase (phosphorylating), 3'-dephospho-CoA kinase, and dephosphocoenzyme A kinase. This enzyme participates in pantothenate and coa biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1JJV, 1N3B, 1T3H, 1VHL, 1VHT, 1VIY, 2GRJ, and 2IF2.

[edit] References

IUBMB entry for 2.7.1.24
BRENDA references for 2.7.1.24 (Recommended.)
PubMed references for 2.7.1.24
PubMed Central references for 2.7.1.24
Google Scholar references for 2.7.1.24
Abiko Y (1970). "Pantothenic acid and coenzyme A:dephospho-CoA pyrophosphorylase and dephospho-CoA kinase as a possible bifunctional enzyme complex (ATP:pantetheine-4'-phosphate adenylyltransferase, EC 2.7.7.3 and ATP:dephospho-CoA-3'-phosphotransferase EC 2.7.1.24)". Methods Enzymol. 18A: 358–364.
HOAGLAND MB, NOVELLI GD (1954). "Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate". J. Biol. Chem. 207: 767–73. PMID 13163064.
Wang TP and Kaplan NO (1954). "Kinases for the synthesis of coenzyme A and triphosphopyridine nucleotide". J. Biol. Chem. 206: 311–325.