Deoxyuridine phosphorylase

From Wikipedia, the free encyclopedia

In enzymology, a deoxyuridine phosphorylase (EC 2.4.2.23) is an enzyme that catalyzes the chemical reaction

2'-deoxyuridine + phosphate uracil + 2-deoxy-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are 2'-deoxyuridine and phosphate, whereas its two products are uracil and 2-deoxy-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is 2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase. This enzyme participates in pyrimidine metabolism.

[edit] References

• IUBMB entry for 2.4.2.23
• BRENDA references for 2.4.2.23 (Recommended.)
• PubMed references for 2.4.2.23
• PubMed Central references for 2.4.2.23
• Google Scholar references for 2.4.2.23
• Soukhova-O'Hare GK, Roberts AM, Gozal D (2006). "Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in rats". Neurosci. Lett. 399: 181–5. doi:10.1016/j.neulet.2006.01.054. PMID 16495004. 
• Yamada EW (1964). "The effect of cortisol administration on the activities of uridine and deoxyuridine phosphorylases of normal and regenerating rat liver". Can. J. Biochem. 42: 317–325. 

[edit] External links

The CAS registry number for this enzyme class is 37277-77-3.

• IUBMB entry for 2.4.2.23

• KEGG entry for 2.4.2.23

• BRENDA entry for 2.4.2.23

• NiceZyme view of 2.4.2.23

• EC2PDB: PDB structures for 2.4.2.23

• PRIAM entry for 2.4.2.23

• PUMA2 entry for 2.4.2.23

• IntEnz: Integrated Enzyme entry for 2.4.2.23

• MetaCyc entry for 2.4.2.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047847: deoxyuridine phosphorylase

• AMIGO entry for GO code 0047847: deoxyuridine phosphorylase