Deoxyguanosine kinase

From Wikipedia, the free encyclopedia

In enzymology, a deoxyguanosine kinase (EC 2.7.1.113) is an enzyme that catalyzes the chemical reaction

ATP + deoxyguanosine $\rightleftharpoons$ ADP + dGMP

Thus, the two substrates of this enzyme are ATP and deoxyguanosine, whereas its two products are ADP and dGMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyguanosine 5'-phosphotransferase. Other names in common use include deoxyguanosine kinase (phosphorylating), (dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, and NTP-deoxyguanosine 5'-phosphotransferase. This enzyme participates in purine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2JAQ, 2JAS, 2JAT, and 2OCP.

[edit] References

IUBMB entry for 2.7.1.113
BRENDA references for 2.7.1.113 (Recommended.)
PubMed references for 2.7.1.113
PubMed Central references for 2.7.1.113
Google Scholar references for 2.7.1.113
Barker J, Lewis RA (1981). "Deoxyguanosine kinase of neonatal mouse skin tissue". Biochim. Biophys. Acta. 658: 111–23. PMID 6260206.
Gower WR Jr, Carr MC, Ives DH (1979). "Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol". J. Biol. Chem. 254: 2180–3. PMID 218928.