Deoxycytidylate 5-hydroxymethyltransferase
From Wikipedia, the free encyclopedia
In enzymology, a deoxycytidylate 5-hydroxymethyltransferase (EC 2.1.2.8) is an enzyme that catalyzes the chemical reaction
- 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, H2O, and deoxycytidylate, whereas its two products are tetrahydrofolate and 5-hydroxymethyldeoxycytidylate.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase. Other names in common use include dCMP hydroxymethylase, d-cytidine 5'-monophosphate hydroxymethylase, deoxyCMP hydroxymethylase, deoxycytidylate hydroxymethylase, and deoxycytidylic hydroxymethylase. This enzyme participates in pyrimidine metabolism and one carbon pool by folate.
Contents |
[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1B49, 1B5D, and 1B5E.
[edit] References
- IUBMB entry for 2.1.2.8
- BRENDA references for 2.1.2.8 (Recommended.)
- PubMed references for 2.1.2.8
- PubMed Central references for 2.1.2.8
- Google Scholar references for 2.1.2.8
- Mathews CK, Brown F and Cohen SS (1964). "Virus-induced acquisition of metabolic function. VII. Biosynthesis de novo of deoxycytidylate hydroxymethylase". J. Biol. Chem. 239: 2957–2963.
[edit] External links
-
- The CAS registry number for this enzyme class is 9012-68-4.
[edit] Gene Ontology (GO) codes
 |
This transferase article is a stub. You can help Wikipedia by expanding it. |
