Deoxyadenosine kinase

From Wikipedia, the free encyclopedia

In enzymology, a deoxyadenosine kinase (EC 2.7.1.76) is an enzyme that catalyzes the chemical reaction

ATP + deoxyadenosine ADP + dAMP

Thus, the two substrates of this enzyme are ATP and deoxyadenosine, whereas its two products are ADP and dAMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyadenosine 5'-phosphotransferase. This enzyme is also called purine-deoxyribonucleoside kinase. This enzyme participates in purine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JAQ.

[edit] References

• IUBMB entry for 2.7.1.76
• BRENDA references for 2.7.1.76 (Recommended.)
• PubMed references for 2.7.1.76
• PubMed Central references for 2.7.1.76
• Google Scholar references for 2.7.1.76
• Chang CH, Brockman RW, Bennett LL Jr (1982). "Purification and some properties of a deoxyribonucleoside kinase from L1210 cells". Cancer. Res. 42: 3033–9. PMID 6284353. 
• Krygier V, Momparler RL (1968). "The regulatory properties of deoxyadenosine kinase". Biochim. Biophys. Acta. 161: 578–80. PMID 5667299. 

[edit] External links

The CAS registry number for this enzyme class is 37278-12-9.

• IUBMB entry for 2.7.1.76

• KEGG entry for 2.7.1.76

• BRENDA entry for 2.7.1.76

• NiceZyme view of 2.7.1.76

• EC2PDB: PDB structures for 2.7.1.76

• PRIAM entry for 2.7.1.76

• PUMA2 entry for 2.7.1.76

• IntEnz: Integrated Enzyme entry for 2.7.1.76

• MetaCyc entry for 2.7.1.76

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004136: deoxyadenosine kinase

• AMIGO entry for GO code 0004136: deoxyadenosine kinase