Delta catenin

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Identifiers
Symbol CTNND1
Alt. Symbols CTNND
Entrez 1500
HUGO 2515
OMIM 601045
RefSeq NM_001331
UniProt O60716
Other data
Locus Chr. 11 q12.1
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Identifiers
Symbol CTNND2
Entrez 1501
HUGO 2516
OMIM 604275
RefSeq NM_001332
UniProt Q9UQB3
Other data
Locus Chr. 5 p15.2

Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3]

While beta-catenin acts as a transcription reglatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor.[4]

[edit] References

  1. ^ I. Israely, R. M. Costa, C. w. Xie, A. J. Silva, K. S. Kosik and X. Liu "Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction" in Current Biology (2004) Volume 14, pages 1657-1663. Entrez PubMed 15380068
  2. ^ M. E. Rubio, C. Curcio, N. Chauvet and J. L. Bruses. "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1" in Molecular and Cellular Neurosciences (2005) Volume 4, pages 611-623. Entrez PubMed 16456928
  3. ^ J. L. Teo, H. Ma, C. Nguyen, C. Lam and M. Kahn. "Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation" in Proceedings of the National Academy of Sciences of the United States of America (2005) Volume 102, pages 12171-12176. Entrez PubMed 16093313
  4. ^ M. Perez-Moreno, M. A. Davis, E. Wong, H. A. Pasolli, A. B. Reynolds, E. Fuchs. "p120-catenin mediates inflammatory responses in the skin" in Cell (2006) Volume 124, pages 631-644. Entrez PubMed 16469707

[edit] See also

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v • d • e
Proteins of the cytoskeleton
Microfilaments
Intermediate filaments
type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B)
Microtubules
Catenins
Nonhuman
Other