Delta24-sterol reductase

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In enzymology, a Delta24-sterol reductase (EC 1.3.1.72) is an enzyme that catalyzes the chemical reaction

5alpha-cholest-7-en-3beta-ol + NADP⁺ 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H⁺

Thus, the two substrates of this enzyme are 5alpha-cholest-7-en-3beta-ol and NADP⁺, whereas its 3 products are 5alpha-cholesta-7,24-dien-3beta-ol, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sterol:NADP+ Delta24-oxidoreductase. This enzyme is also called lanosterol Delta24-reductase. This enzyme participates in biosynthesis of steroids.

[edit] References

• IUBMB entry for 1.3.1.72
• BRENDA references for 1.3.1.72 (Recommended.)
• PubMed references for 1.3.1.72
• PubMed Central references for 1.3.1.72
• Google Scholar references for 1.3.1.72
• Bae SH, Paik YK (Pt 2). "Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase". Biochem. J. 326: 609–16. PMID 9291139. 

[edit] External links

• IUBMB entry for 1.3.1.72

• KEGG entry for 1.3.1.72

• BRENDA entry for 1.3.1.72

• NiceZyme view of 1.3.1.72

• EC2PDB: PDB structures for 1.3.1.72

• PRIAM entry for 1.3.1.72

• PUMA2 entry for 1.3.1.72

• IntEnz: Integrated Enzyme entry for 1.3.1.72

• MetaCyc entry for 1.3.1.72

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050614: delta24-sterol reductase

• AMIGO entry for GO code 0050614: delta24-sterol reductase