Delta12-fatty acid dehydrogenase

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In enzymology, a Delta12-fatty acid dehydrogenase (EC 1.14.99.33) is an enzyme that catalyzes the chemical reaction

linoleate + AH₂ + O₂ $\rightleftharpoons$ crepenynate + A + H₂O

The 3 substrates of this enzyme are linoleate, AH2, and O₂, whereas its 3 products are crepenynate, A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating). Other names in common use include crepenynate synthase, and linoleate Delta12-fatty acid acetylenase (desaturase). This enzyme participates in linoleic acid metabolism.

[edit] References

IUBMB entry for 1.14.99.33
BRENDA references for 1.14.99.33 (Recommended.)
PubMed references for 1.14.99.33
PubMed Central references for 1.14.99.33
Google Scholar references for 1.14.99.33
S (1997). "Biosynthesis of an acetylenic fatty acid in microsomal preparations from developing seeds Crepis alpina. Physiol. Biochem. Mol". Biol. Plant. 12th: 57–59.
S (1998). "Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation". Science. 280: 915–8. doi:10.1126/science.280.5365.915. PMID 9572738.