Delta1-piperideine-2-carboxylate reductase

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In enzymology, a Delta1-piperideine-2-carboxylate reductase (EC 1.5.1.21) is an enzyme that catalyzes the chemical reaction

L-pipecolate + NADP⁺ Delta₁-piperideine-2-carboxylate + NADPH + H⁺

Thus, the two substrates of this enzyme are L-pipecolate and NADP⁺, whereas its 3 products are Delta1-piperideine-2-carboxylate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-pipecolate:NADP+ 2-oxidoreductase. Other names in common use include 1,2-didehydropipecolate reductase, P2C reductase, and 1,2-didehydropipecolic reductase. This enzyme participates in lysine degradation.

[edit] References

• IUBMB entry for 1.5.1.21
• BRENDA references for 1.5.1.21 (Recommended.)
• PubMed references for 1.5.1.21
• PubMed Central references for 1.5.1.21
• Google Scholar references for 1.5.1.21
• Payton CW, Chang YF (1982). "delta1-piperideine-2-carboxylate reductase of Pseudomonas putida". J. Bacteriol. 149: 864–71. PMID 6801013. 

[edit] External links

The CAS registry number for this enzyme class is 52037-88-4.

• IUBMB entry for 1.5.1.21

• KEGG entry for 1.5.1.21

• BRENDA entry for 1.5.1.21

• NiceZyme view of 1.5.1.21

• EC2PDB: PDB structures for 1.5.1.21

• PRIAM entry for 1.5.1.21

• PUMA2 entry for 1.5.1.21

• IntEnz: Integrated Enzyme entry for 1.5.1.21

• MetaCyc entry for 1.5.1.21

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047125: delta1-piperideine-2-carboxylate reductase

• AMIGO entry for GO code 0047125: delta1-piperideine-2-carboxylate reductase