Dehydrogluconate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a dehydrogluconate dehydrogenase (EC 1.1.99.4) is an enzyme that catalyzes the chemical reaction

2-dehydro-D-gluconate + acceptor 2,5-didehydro-D-gluconate + reduced acceptor

Thus, the two substrates of this enzyme are 2-dehydro-D-gluconate and acceptor, whereas its two products are 2,5-didehydro-D-gluconate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is 2-dehydro-D-gluconate:acceptor 2-oxidoreductase. Other names in common use include ketogluconate dehydrogenase, alpha-ketogluconate dehydrogenase, 2-keto-D-gluconate dehydrogenase, and 2-oxogluconate dehydrogenase. It has 2 cofactors: FAD, and Flavoprotein.

[edit] References

• IUBMB entry for 1.1.99.4
• BRENDA references for 1.1.99.4 (Recommended.)
• PubMed references for 1.1.99.4
• PubMed Central references for 1.1.99.4
• Google Scholar references for 1.1.99.4
• DATTA AG, KATZNELSON H (1956). "The oxidation of 2-ketogluconate by a partially purified enzyme from Acetobactor melanogenum". Arch. Biochem. Biophys. 65: 576–8. doi:10.1016/0003-9861(56)90218-1. PMID 13395514. 
• Shinagawa E and Ameyama M (1982). "2-Keto-D-gluconate dehydrogenase from Gluconobacter melanogenus, membrane-bound". Methods Enzymol. 89: 194–198. 

[edit] External links

The CAS registry number for this enzyme class is 9028-82-4.

• IUBMB entry for 1.1.99.4

• KEGG entry for 1.1.99.4

• BRENDA entry for 1.1.99.4

• NiceZyme view of 1.1.99.4

• EC2PDB: PDB structures for 1.1.99.4

• PRIAM entry for 1.1.99.4

• PUMA2 entry for 1.1.99.4

• IntEnz: Integrated Enzyme entry for 1.1.99.4

• MetaCyc entry for 1.1.99.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047843: dehydrogluconate dehydrogenase

• AMIGO entry for GO code 0047843: dehydrogluconate dehydrogenase