DEFB127

From Wikipedia, the free encyclopedia


Defensin, beta 127
Identifiers
Symbol(s) DEFB127; C20orf73; DEF-27; DEFB-27; DEFB27; bA530N10.2; hBD-27
External IDs HomoloGene: 89142
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 140850 n/a
Ensembl ENSG00000088782 n/a
Uniprot Q9H1M4 n/a
Refseq NM_139074 (mRNA)
NP_620713 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 20: 0.09 - 0.09 Mb n/a
Pubmed search [1] n/a

Defensin, beta 127, also known as DEFB127, is a human gene.[1]

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.[1]

[edit] References

  1. ^ a b Entrez Gene: DEFB127 defensin, beta 127.

[edit] Further reading

  • van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS (2000). "Defensins: key players or bystanders in infection, injury, and repair in the lung?". J. Allergy Clin. Immunol. 104 (6): 1131-8. PMID 10588992. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.". Genomics 81 (2): 175-83. PMID 12620395. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Schutte BC, Mitros JP, Bartlett JA, et al. (2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy.". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 2129-33. doi:10.1073/pnas.042692699. PMID 11854508. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
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