DEFB126

From Wikipedia, the free encyclopedia

Defensin, beta 126

Identifiers

DEFB126; C20orf8; DEFB-26; DEFB26; ESP13.2; bA530N10.1; hBD-26

External IDs

Gene ontology
Molecular Function:	• protease inhibitor activity
Cellular Component:	• extracellular region
Biological Process:	• proteolysis • defense response to bacterium

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_030931 (mRNA)
NP_112193 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 20: 0.07 - 0.07 Mb

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Pubmed search

[1]

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Defensin, beta 126, also known as DEFB126, is a human gene.^[1]

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey.^[1]

[edit] References

^ ^a ^b Entrez Gene: DEFB126 defensin, beta 126.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.". Genomics 81 (2): 175-83. PMID 12620395.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Schutte BC, Mitros JP, Bartlett JA, et al. (2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy.". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 2129-33. doi:10.1073/pnas.042692699. PMID 11854508.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Perry AC, Jones R, Moisyadi S, et al. (1999). "The novel epididymal secretory protein ESP13.2 in Macaca fascicularis.". Biol. Reprod. 61 (4): 965-72. PMID 10491631.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.