Decamethonium

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Decamethonium
Systematic (IUPAC) name
trimethyl-(10-trimethylammoniodecyl)ammonium
Identifiers
CAS number	156-74-1
ATC code	?
PubChem	2968
DrugBank	APRD00696
Chemical data
Formula	C₁₆H₃₈N_{2 +}
Mol. mass	258.486 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Decamethonium bromide (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis.

Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate--but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

Decamethonium does not produce unconsciousness or anesthesia, and its effects may cause considerable psychological distress while simultaneously making it impossible for a patient to communicate. For these reasons, administration of the drug to a conscious patient is strongly contraindicated, except in necessary emergency situations.