DDEF1

From Wikipedia, the free encyclopedia

Development and differentiation enhancing factor 1

PDB rendering based on 2da0.

Available structures: 2da0

Identifiers

Symbol(s)

DDEF1; PAP; AMAP1; ASAP1; KIAA1249; PAG2; ZG14P

External IDs

OMIM: 605953 MGI: 1342335 HomoloGene: 7684

Gene ontology
Molecular Function:	• GTPase activator activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• membrane
Biological Process:	• regulation of GTPase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018482 (mRNA)
NP_060952 (protein)

XM_976874 (mRNA)
XP_981968 (protein)

Location

Chr 8: 131.13 - 131.48 Mb

Chr 15: 63.92 - 64.21 Mb

Pubmed search

[1]

[2]

Development and differentiation enhancing factor 1, also known as DDEF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: DDEF1 development and differentiation enhancing factor 1.

[edit] Further reading

Brown MT, Andrade J, Radhakrishna H, et al. (1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.". Mol. Cell. Biol. 18 (12): 7038–51. PMID 9819391.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462.
Furman C, Short SM, Subramanian RR, et al. (2002). "DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.". J. Biol. Chem. 277 (10): 7962–9. doi:10.1074/jbc.M109149200. PMID 11773070.
Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
Liu Y, Loijens JC, Martin KH, et al. (2002). "The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.". Mol. Biol. Cell 13 (6): 2147–56. doi:10.1091/mbc.E02-01-0018. PMID 12058076.
Oshiro T, Koyama S, Sugiyama S, et al. (2002). "Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.". J. Biol. Chem. 277 (41): 38618–26. doi:10.1074/jbc.M203453200. PMID 12149250.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Oda A, Wada I, Miura K, et al. (2003). "CrkL directs ASAP1 to peripheral focal adhesions.". J. Biol. Chem. 278 (8): 6456–60. doi:10.1074/jbc.M210817200. PMID 12522101.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Onodera Y, Hashimoto S, Hashimoto A, et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.". EMBO J. 24 (5): 963–73. doi:10.1038/sj.emboj.7600588. PMID 15719014.
Ehlers JP, Worley L, Onken MD, Harbour JW (2005). "DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma.". Clin. Cancer Res. 11 (10): 3609–13. doi:10.1158/1078-0432.CCR-04-1941. PMID 15897555.
Che MM, Boja ES, Yoon HY, et al. (2005). "Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains.". Cell. Signal. 17 (10): 1276–88. doi:10.1016/j.cellsig.2005.01.007. PMID 16038802.
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8.". Nature 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
Hashimoto S, Hirose M, Hashimoto A, et al. (2006). "Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.". Proc. Natl. Acad. Sci. U.S.A. 103 (18): 7036–41. doi:10.1073/pnas.0509166103. PMID 16636290.