dCTP diphosphatase

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In enzymology, a dCTP diphosphatase (EC 3.6.1.12) is an enzyme that catalyzes the chemical reaction

dCTP + H₂O dCMP + diphosphate

Thus, the two substrates of this enzyme are dCTP and H₂O, whereas its two products are dCMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dCTP nucleotidohydrolase. Other names in common use include deoxycytidine-triphosphatase, dCTPase, dCTP pyrophosphatase, deoxycytidine triphosphatase, deoxy-CTPase, and dCTPase. This enzyme participates in pyrimidine metabolism.

[edit] References

• IUBMB entry for 3.6.1.12
• BRENDA references for 3.6.1.12 (Recommended.)
• PubMed references for 3.6.1.12
• PubMed Central references for 3.6.1.12
• Google Scholar references for 3.6.1.12
• Zimmerman SB and Kornberg A (1961). "Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Escherichia coli". J. Biol. Chem. 236: 1480–1486. 

[edit] External links

The CAS registry number for this enzyme class is 9024-87-7.

• IUBMB entry for 3.6.1.12

• KEGG entry for 3.6.1.12

• BRENDA entry for 3.6.1.12

• NiceZyme view of 3.6.1.12

• EC2PDB: PDB structures for 3.6.1.12

• PRIAM entry for 3.6.1.12

• PUMA2 entry for 3.6.1.12

• IntEnz: Integrated Enzyme entry for 3.6.1.12

• MetaCyc entry for 3.6.1.12

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047840: dCTP diphosphatase

• AMIGO entry for GO code 0047840: dCTP diphosphatase