dCTP deaminase

From Wikipedia, the free encyclopedia

In enzymology, a dCTP deaminase (EC 3.5.4.13) is an enzyme that catalyzes the chemical reaction

dCTP + H₂O dUTP + NH₃

Thus, the two substrates of this enzyme are dCTP and H₂O, whereas its two products are dUTP and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase. Other names in common use include deoxycytidine triphosphate deaminase, and 5-methyl-dCTP deaminase. This enzyme participates in pyrimidine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1OGH, 1PKH, 1PKJ, 1PKK, 1XS1, 1XS4, 1XS6, 2J4H, and 2J4Q.

[edit] References

• IUBMB entry for 3.5.4.13
• BRENDA references for 3.5.4.13 (Recommended.)
• PubMed references for 3.5.4.13
• PubMed Central references for 3.5.4.13
• Google Scholar references for 3.5.4.13
• Tomita F, Takahashi I (1969). "A novel enzyme, dCTP deaminase, found in Bacillus subtilis infected with phage PBS I". Biochim. Biophys. Acta. 179: 18–27. PMID 4976547. 

[edit] External links

The CAS registry number for this enzyme class is 37289-18-2.

• IUBMB entry for 3.5.4.13

• KEGG entry for 3.5.4.13

• BRENDA entry for 3.5.4.13

• NiceZyme view of 3.5.4.13

• EC2PDB: PDB structures for 3.5.4.13

• PRIAM entry for 3.5.4.13

• PUMA2 entry for 3.5.4.13

• IntEnz: Integrated Enzyme entry for 3.5.4.13

• MetaCyc entry for 3.5.4.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008829: dCTP deaminase

• AMIGO entry for GO code 0008829: dCTP deaminase