dCTP deaminase (dUMP-forming)

From Wikipedia, the free encyclopedia

In enzymology, a dCTP deaminase (dUMP-forming) (EC 3.5.4.30) is an enzyme that catalyzes the chemical reaction

dCTP + 2 H₂O dUMP + diphosphate + NH₃

Thus, the two substrates of this enzyme are dCTP and H₂O, whereas its 3 products are dUMP, diphosphate, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HXB, 2HXD, and 2HXE.

[edit] References

• IUBMB entry for 3.5.4.30
• BRENDA references for 3.5.4.30 (Recommended.)
• PubMed references for 3.5.4.30
• PubMed Central references for 3.5.4.30
• Google Scholar references for 3.5.4.30
• Li H, Xu H, Graham DE, White RH (2003). "The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase". J. Biol. Chem. 278: 11100–6. doi:10.1074/jbc.M212460200. PMID 12538648. 

[edit] External links

• IUBMB entry for 3.5.4.30

• KEGG entry for 3.5.4.30

• BRENDA entry for 3.5.4.30

• NiceZyme view of 3.5.4.30

• EC2PDB: PDB structures for 3.5.4.30

• PRIAM entry for 3.5.4.30

• PUMA2 entry for 3.5.4.30

• IntEnz: Integrated Enzyme entry for 3.5.4.30

• MetaCyc entry for 3.5.4.30

• Atomic-resolution structures of enzymes belonging to this class