DCP2

From Wikipedia, the free encyclopedia

DCP2 decapping enzyme homolog (S. cerevisiae)

Identifiers

DCP2; FLJ33245; NUDT20

External IDs

OMIM: 609844 MGI: 1917890 HomoloGene: 13968

Gene ontology
Molecular Function:	• RNA binding • protein binding • hydrolase activity • manganese ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• mRNA catabolic process, nonsense-mediated decay

Orthologs

Human

Mouse

Refseq

NM_152624 (mRNA)
NP_689837 (protein)

XM_140308 (mRNA)
XP_140308 (protein)

Location

Chr 5: 112.34 - 112.38 Mb

Chr 18: 44.51 - 44.54 Mb

Pubmed search

[1]

[2]

DCP2 decapping enzyme homolog (S. cerevisiae), also known as DCP2, is a human gene.^[1]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae).

[edit] Further reading

Ueno K, Kumagai T, Kijima T, et al. (1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer.". Hum. Genet. 102 (1): 63-8. PMID 9490301.
Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12663-8. doi:10.1073/pnas.192445599. PMID 12218187.
Lykke-Andersen J (2003). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.". Mol. Cell. Biol. 22 (23): 8114-21. PMID 12417715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
van Dijk E, Cougot N, Meyer S, et al. (2004). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.". EMBO J. 21 (24): 6915-24. PMID 12486012.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.". RNA 8 (12): 1489-501. PMID 12515382.
Grzymski EC (2003). "Visualizing an mRNA destruction line.". Nat. Struct. Biol. 10 (6): 416. doi:10.1038/nsb0603-416. PMID 12768200.
Piccirillo C, Khanna R, Kiledjian M (2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2.". RNA 9 (9): 1138-47. PMID 12923261.
Lejeune F, Li X, Maquat LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.". Mol. Cell 12 (3): 675-87. PMID 14527413.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Cougot N, Babajko S, Séraphin B (2004). "Cytoplasmic foci are sites of mRNA decay in human cells.". J. Cell Biol. 165 (1): 31-40. doi:10.1083/jcb.200309008. PMID 15067023.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Liu SW, Jiao X, Liu H, et al. (2004). "Functional analysis of mRNA scavenger decapping enzymes.". RNA 10 (9): 1412-22. doi:10.1261/rna.7660804. PMID 15273322.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.". Nat. Cell Biol. 7 (7): 719-23. doi:10.1038/ncb1274. PMID 15937477.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.". Mol. Cell 20 (6): 905-15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.". PLoS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMID 16699599.
Chu CY, Rana TM (2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.". PLoS Biol. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMID 16756390.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.