DCLRE1A

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DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)
Identifiers
Symbol(s) DCLRE1A; KIAA0086; PSO2; SNM1
External IDs OMIM: 609682 MGI: 1930042 HomoloGene: 8920
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9937 55947
Ensembl ENSG00000198924 ENSMUSG00000025077
Uniprot Q6PJP8 Q9JIC3
Refseq NM_014881 (mRNA)
NP_055696 (protein)		 NM_018831 (mRNA)
NP_061301 (protein)
Location Chr 10: 115.58 - 115.6 Mb Chr 19: 56.58 - 56.6 Mb
Pubmed search [1] [2]

DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae), also known as DCLRE1A, is a human gene.[1]

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: DCLRE1A DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae).

[edit] Further reading

  • Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527. 
  • Demuth I, Digweed M (1998). "Genomic organization of a potential human DNA-crosslink repair gene, KIAA0086.". Mutat. Res. 409 (1): 11–6. PMID 9806498. 
  • Dronkert ML, de Wit J, Boeve M, et al. (2000). "Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.". Mol. Cell. Biol. 20 (13): 4553–61. PMID 10848582. 
  • Richie CT, Peterson C, Lu T, et al. (2003). "hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.". Mol. Cell. Biol. 22 (24): 8635–47. PMID 12446782. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zhang X, Richie C, Legerski RJ (2003). "Translation of hSNM1 is mediated by an internal ribosome entry site that upregulates expression during mitosis.". DNA Repair (Amst.) 1 (5): 379–90. PMID 12509242. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Akhter S, Richie CT, Deng JM, et al. (2005). "Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.". Mol. Cell. Biol. 24 (23): 10448–55. doi:10.1128/MCB.24.23.10448-10455.2004. PMID 15542852. 
  • Ishiai M, Kimura M, Namikoshi K, et al. (2004). "DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation.". Mol. Cell. Biol. 24 (24): 10733–41. doi:10.1128/MCB.24.24.10733-10741.2004. PMID 15572677. 
  • Hejna J, Philip S, Ott J, et al. (2007). "The hSNM1 protein is a DNA 5'-exonuclease.". Nucleic Acids Res. 35 (18): 6115–23. doi:10.1093/nar/gkm530. PMID 17804464. 
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