DCLK1

From Wikipedia, the free encyclopedia

Doublecortin and CaM kinase-like 1

PDB rendering based on 1mfw.

Available structures: 1mfw, 1mg4, 1uf0

Identifiers

Symbol(s)

DCAMKL1; DCDC3A; DCLK; KIAA0369

External IDs

OMIM: 604742 MGI: 1330861 HomoloGene: 74530

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • receptor signaling protein activity • protein binding • ATP binding • kinase activity • transferase activity
Cellular Component:	• integral to plasma membrane
Biological Process:	• neuron migration • protein amino acid phosphorylation • intracellular signaling cascade • multicellular organismal development • axonogenesis • central nervous system development • endosome transport • cell differentiation • forebrain development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004734 (mRNA)
NP_004725 (protein)

NM_019978 (mRNA)
NP_064362 (protein)

Location

Chr 13: 35.24 - 35.6 Mb

Chr 3: 55.33 - 55.62 Mb

Pubmed search

[1]

[2]

Doublecortin and CaM kinase-like 1, also known as DCAMKL1, is a human gene.^[1]

[edit] References

^ Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1.

[edit] Further reading

Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141-50. PMID 9205841.
Omori Y, Suzuki M, Ozaki K, et al. (1998). "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin.". J. Hum. Genet. 43 (3): 169-77. PMID 9747029.
Sossey-Alaoui K, Srivastava AK (1999). "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX).". Genomics 56 (1): 121-6. doi:10.1006/geno.1998.5718. PMID 10036192.
Matsumoto N, Pilz DT, Ledbetter DH (1999). "Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS).". Genomics 56 (2): 179-83. doi:10.1006/geno.1998.5673. PMID 10051403.
Lin PT, Gleeson JG, Corbo JC, et al. (2001). "DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization.". J. Neurosci. 20 (24): 9152-61. PMID 11124993.
Burgess HA, Reiner O (2002). "Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities.". J. Biol. Chem. 277 (20): 17696-705. doi:10.1074/jbc.M111981200. PMID 11884394.
Kim MH, Derewenda U, Devedjiev Y, et al. (2003). "Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase.". Acta Crystallogr. D Biol. Crystallogr. 59 (Pt 3): 502-5. PMID 12595708.
Kim MH, Cierpicki T, Derewenda U, et al. (2003). "The DCX-domain tandems of doublecortin and doublecortin-like kinase.". Nat. Struct. Biol. 10 (5): 324-33. doi:10.1038/nsb918. PMID 12692530.
Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes.". J. Biol. Chem. 279 (6): 4670-9. doi:10.1074/jbc.M311228200. PMID 14613930.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.