DBR1

From Wikipedia, the free encyclopedia

Debranching enzyme homolog 1 (S. cerevisiae)

Identifiers

External IDs

OMIM: 607024 MGI: 1931520 HomoloGene: 9428

Gene ontology
Molecular Function:	• RNA lariat debranching enzyme activity • hydrolase activity, acting on ester bonds • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• RNA splicing, via transesterification reactions • nuclear mRNA splicing, via spliceosome

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016216 (mRNA)
NP_057300 (protein)

NM_031403 (mRNA)
NP_113580 (protein)

Location

Chr 3: 139.36 - 139.38 Mb

Chr 9: 99.39 - 99.39 Mb

Pubmed search

[1]

[2]

Debranching enzyme homolog 1 (S. cerevisiae), also known as DBR1, is a human gene.^[1]

The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae).

[edit] Further reading

Chapman KB, Boeke JD (1991). "Isolation and characterization of the gene encoding yeast debranching enzyme.". Cell 65 (3): 483-92. PMID 1850323.
Arenas J, Hurwitz J (1987). "Purification of a RNA debranching activity from HeLa cells.". J. Biol. Chem. 262 (9): 4274-9. PMID 2435736.
Kim JW, Kim HC, Kim GM, et al. (2000). "Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants.". Nucleic Acids Res. 28 (18): 3666-73. PMID 10982890.
Martin A, Schneider S, Schwer B (2002). "Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome.". J. Biol. Chem. 277 (20): 17743-50. doi:10.1074/jbc.M200762200. PMID 11886864.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ye Y, De Leon J, Yokoyama N, et al. (2006). "DBR1 siRNA inhibition of HIV-1 replication.". Retrovirology 2: 63. doi:10.1186/1742-4690-2-63. PMID 16232320.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.