DBN1

From Wikipedia, the free encyclopedia

Drebrin 1

Identifiers

DBN1; D0S117E; DKFZp434D064

External IDs

OMIM: 126660 MGI: 1931838 HomoloGene: 3236

Gene ontology
Molecular Function:	• actin binding • profilin binding
Cellular Component:	• intracellular • cytoplasm • plasma membrane • actin cytoskeleton • dendrite • actomyosin
Biological Process:	• actin filament organization • multicellular organismal development • nervous system development • cell differentiation • regulation of neuronal synaptic plasticity • regulation of dendrite development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004395 (mRNA)
NP_004386 (protein)

NM_019813 (mRNA)
NP_062787 (protein)

Location

Chr 5: 176.82 - 176.83 Mb

Chr 13: 55.48 - 55.5 Mb

Pubmed search

[1]

[2]

Drebrin 1, also known as DBN1, is a human gene.^[1]

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: DBN1 drebrin 1.

[edit] Further reading

Shirao T (1995). "The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review.". J. Biochem. 117 (2): 231–6. PMID 7608104.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Toda M, Shirao T, Minoshima S, et al. (1993). "Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene.". Biochem. Biophys. Res. Commun. 196 (1): 468–72. doi:10.1006/bbrc.1993.2273. PMID 8216329.
Harigaya Y, Shoji M, Shirao T, Hirai S (1996). "Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease.". J. Neurosci. Res. 43 (1): 87–92. doi:10.1002/jnr.490430111. PMID 8838578.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Mammoto A, Sasaki T, Asakura T, et al. (1998). "Interactions of drebrin and gephyrin with profilin.". Biochem. Biophys. Res. Commun. 243 (1): 86–9. doi:10.1006/bbrc.1997.8068. PMID 9473484.
Hayashi K, Ishikawa R, Kawai-Hirai R, et al. (2000). "Domain analysis of the actin-binding and actin-remodeling activities of drebrin.". Exp. Cell Res. 253 (2): 673–80. doi:10.1006/excr.1999.4663. PMID 10585290.
Peitsch WK, Grund C, Kuhn C, et al. (2000). "Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells.". Eur. J. Cell Biol. 78 (11): 767–78. PMID 10604653.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Kobayashi S, Shirao T, Sasaki T (2001). "Drebrin expression is increased in spinal motoneurons of rats after axotomy.". Neurosci. Lett. 311 (3): 165–8. PMID 11578820.
Shim KS, Lubec G (2002). "Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome.". Neurosci. Lett. 324 (3): 209–12. PMID 12009525.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T (2003). "Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons.". Mol. Cell. Neurosci. 22 (2): 188–201. PMID 12676529.
Peitsch WK, Hofmann I, Endlich N, et al. (2003). "Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli.". J. Am. Soc. Nephrol. 14 (6): 1452–63. PMID 12761245.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.