DAZ associated protein 1

From Wikipedia, the free encyclopedia

PDB rendering based on 2dgs.

Available structures: 2dgs, 2dh8

Identifiers

Symbol(s)

DAZAP1; MGC19907

External IDs

OMIM: 607430 MGI: 1917498 HomoloGene: 23129

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• multicellular organismal development • spermatogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018959 (mRNA)
NP_061832 (protein)

XM_986609 (mRNA)
XP_991703 (protein)

Location

Chr 19: 1.36 - 1.39 Mb

Chr 10: 79.67 - 79.69 Mb

Pubmed search

[1]

[2]

DAZ associated protein 1, also known as DAZAP1, is a human gene.^[1]

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: DAZAP1 DAZ associated protein 1.

[edit] Further reading

Tsui S, Dai T, Roettger S, et al. (2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.". Genomics 65 (3): 266-73. doi:10.1006/geno.2000.6169. PMID 10857750.
Dai T, Vera Y, Salido EC, Yen PH (2003). "Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.". BMC Genomics 2 (1): 6. PMID 11604102.
Vera Y, Dai T, Hikim AP, et al. (2003). "Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation.". J. Androl. 23 (5): 622-8. PMID 12185095.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Prima V, Gore L, Caires A, et al. (2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia.". Leukemia 19 (5): 806-13. doi:10.1038/sj.leu.2403684. PMID 15744350.
Pan HA, Lin YS, Lee KH, et al. (2006). "Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries.". Fertil. Steril. 84 Suppl 2: 1089-94. doi:10.1016/j.fertnstert.2005.03.075. PMID 16209998.
Morton S, Yang HT, Moleleki N, et al. (2006). "Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ.". Biochem. J. 399 (2): 265-73. doi:10.1042/BJ20060681. PMID 16848763.