David Jaffray

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David A. Jaffray PhD is a Canadian medical physicist and Senior Scientist in the Division of Biophysics and Bioimaging at the Ontario Cancer Institute. He is also an associate professor at the University of Toronto's Department of Radiation Oncology. He is the inventor, together with John Wong, of on line volumetric kv-imaging guidance system for radiation therapy^{[citation needed]}.

Jaffray's work focuses on the development of novel imaging systems and concepts to improve the precision of therapy by generating images at the time of therapy for the purpose of guiding the treatment delivery. Recent developments have included the construction of megavoltage and kilovoltage imaging systems based upon high-performance charged coupled device cameras, prototyping, and evaluation of amorphous-silicon based large-area detectors for megavoltage work^{[citation needed]}.

In addition, a kilovoltage cone-beam computed tomography (CT) system has been developed. These systems have been integrated with the megavoltage treatment devices to improve the precision with which the therapy could be executed without the interference of mechanical immobilization systems. The cone-beam CT approach has also been extended to a mobile C-arm for intra-operative imaging and therapy guidance.

A direct by-product of these investigations is the development of clinical processes that can use the images generated by these systems in a sensible and robust fashion. The development of such image-guidance processes is an active area of ongoing research in the program. This area has been broadened through the use of cinematographic magnetic resonance imaging (MR) sequences that permit the spatial instabilities that are inherent in the human body to be assessed. These assessments describe a lower limit on the precision with which non-invasive therapy can be applied and they must be considered in the development of robust treatment regimens.

He was named as one of "Canada's Top 40 Under 40" in 2003 by Caldwell Partners.^[1]