David Charles Baulcombe

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David Charles Baulcombe
Born	1952
Fields	genetic, gene silencing
Known for	small interfering RNA

David Charles Baulcombe (born 1952) is a plant scientist and geneticist with interests in genetic regulation, genetic disease resistance and gene silencing. With Andrew Hamilton he discovered the small interfering RNA that is the specificity determinant in RNA-mediated gene silencing and, with other members of his research group, he helped unravel the importance of small interfering RNA in defense against viruses and in epigenetics.

Baulcombe's career as an independent scientist started at the Plant Breeding Institute in Cambridge and continued between 1988 and 2007 at the Sainsbury Laboratory in Norwich. In March 2007, it was announced that Baulcombe would be the next Professor of Botany at Cambridge University, taking up his post in September 2007.^[1] He was elected to the Royal Society in 2001 and the United States National Academy of Sciences in 2005. His honours and awards include the Royal Netherlands Academy of Arts and Sciences's M. W. Beijerinck Virology Prize (2004) and the Royal Society's Royal Medal (2006).

As of 2007, Baulcombe is a senior editor for The Embo Journal.^[2]

[edit] Publications

• Hamilton, Andrew; Voinnet, Olivier; Chappell, Louise & Baulcombe, David (2002), “Two classes of short interfering RNA in RNA silencing.”, EMBO J. 21 (17): 4671-9, 2002 Sep 2, PMID:12198169, <http://www.ncbi.nlm.nih.gov/pubmed/12198169> 
• Papaefthimiou, I; Hamilton, A; Denti, M & Baulcombe, D (2001), “Replicating potato spindle tuber viroid RNA is accompanied by short RNA fragments that are characteristic of post-transcriptional gene silencing.”, Nucleic Acids Res. 29 (11): 2395-400, 2001 Jun 1, PMID:11376158, <http://www.ncbi.nlm.nih.gov/pubmed/11376158> 
• Dalmay, T; Hamilton, A; Rudd, S & Angell, S (2000), “An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus.”, Cell 101 (5): 543-53, 2000 May 26, PMID:10850496, <http://www.ncbi.nlm.nih.gov/pubmed/10850496> 
• Burton, R A; Gibeaut, D M; Bacic, A & Findlay, K (2000), “Virus-induced silencing of a plant cellulose synthase gene.”, Plant Cell 12 (5): 691-706, 2000 May, PMID:10810144, <http://www.ncbi.nlm.nih.gov/pubmed/10810144> 
• Dalmay, T; Hamilton, A; Mueller, E & Baulcombe, D C (2000), “Potato virus X amplicons in arabidopsis mediate genetic and epigenetic gene silencing.”, Plant Cell 12 (3): 369-79, 2000 Mar, PMID:10715323, <http://www.ncbi.nlm.nih.gov/pubmed/10715323> 
• Jones, L; Hamilton, A J; Voinnet, O & Thomas, C L (1999), “RNA-DNA interactions and DNA methylation in post-transcriptional gene silencing.”, Plant Cell 11 (12): 2291-301, 1999 Dec, PMID:10590159, <http://www.ncbi.nlm.nih.gov/pubmed/10590159> 
• Hamilton, A J & Baulcombe, D C (1999), “A species of small antisense RNA in posttranscriptional gene silencing in plants.”, Science 286 (5441): 950-2, 1999 Oct 29, PMID:10577233, <http://www.ncbi.nlm.nih.gov/pubmed/10577233> 
• Hamilton, W D; Boccara, M; Robinson, D J & Baulcombe, D C (1987), “The complete nucleotide sequence of tobacco rattle virus RNA-1.”, J. Gen. Virol. 68 ( Pt 10): 2563-75, 1987 Oct, PMID:3668507, <http://www.ncbi.nlm.nih.gov/pubmed/3668507> 
• Boccara; Hamilton & Baulcombe (1986), The organisation and interviral homologies of genes at the 3' end of tobacco rattle virus RNA1., vol. 5 (published 1986 Feb), pp. 223-229, PMID:16453668, <http://www.ncbi.nlm.nih.gov/pubmed/16453668> 

[edit] References

1. ^ Cambridge University Department of Plant Sciences news
2. ^ Embo editorial board

[edit] External links

• Interview with Professor Balcombe from in-cites website
• Biography from the American Phytopathological Society 2002 Awards (p.4)