DARS (gene)

From Wikipedia, the free encyclopedia

Aspartyl-tRNA synthetase

Identifiers

DARS; DKFZp781B11202; MGC111579

External IDs

OMIM: 603084 MGI: 2442544 HomoloGene: 1032

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • aminoacylase activity • aspartate-tRNA ligase activity • ATP binding • ligase activity
Cellular Component:	• soluble fraction • cytoplasm
Biological Process:	• aspartyl-tRNA aminoacylation • protein complex assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001349 (mRNA)
NP_001340 (protein)

NM_145507 (mRNA)
NP_663482 (protein)

Location

Chr 2: 136.38 - 136.46 Mb

Chr 1: 130.19 - 130.24 Mb

Pubmed search

[1]

[2]

Aspartyl-tRNA synthetase, also known as DARS, is a human gene.^[1]

Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetase charges its cognate tRNA with aspartate during protein biosynthesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: DARS aspartyl-tRNA synthetase.

[edit] Further reading

Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents.". J. Biol. Chem. 266 (23): 15398-405. PMID 1651330.
Jacobo-Molina A, Peterson R, Yang DC (1989). "cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase.". J. Biol. Chem. 264 (28): 16608-12. PMID 2674137.
Reed VS, Wastney ME, Yang DC (1995). "Mechanisms of the transfer of aminoacyl-tRNA from aminoacyl-tRNA synthetase to the elongation factor 1 alpha.". J. Biol. Chem. 269 (52): 32932-6. PMID 7806521.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Escalante C, Yang DC (1993). "Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix.". J. Biol. Chem. 268 (8): 6014-23. PMID 8449960.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.". J. Mol. Biol. 285 (1): 183-95. doi:10.1006/jmbi.1998.2316. PMID 9878398.
Rho SB, Kim MJ, Lee JS, et al. (1999). "Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex.". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4488-93. PMID 10200289.
Kang J, Kim T, Ko YG, et al. (2000). "Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases.". J. Biol. Chem. 275 (41): 31682-8. doi:10.1074/jbc.M909965199. PMID 10913161.
Sang Lee J, Gyu Park S, Park H, et al. (2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.". Biochem. Biophys. Res. Commun. 291 (1): 158-64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cheong HK, Park JY, Kim EH, et al. (2004). "Structure of the N-terminal extension of human aspartyl-tRNA synthetase: implications for its biological function.". Int. J. Biochem. Cell Biol. 35 (11): 1548-57. PMID 12824064.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Bonnefond L, Fender A, Rudinger-Thirion J, et al. (2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.". Biochemistry 44 (12): 4805-16. doi:10.1021/bi047527z. PMID 15779907.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics 6 (4): 575-88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.