DAPK3

From Wikipedia, the free encyclopedia

Death-associated protein kinase 3

PDB rendering based on 1yrp.

Available structures: 1yrp, 2j90

Identifiers

Symbol(s)

DAPK3; FLJ36473; ZIP; ZIPK

External IDs

OMIM: 603289 MGI: 1203520 HomoloGene: 20353

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation • apoptosis • induction of apoptosis • protein kinase cascade • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001348 (mRNA)
NP_001339 (protein)

NM_007828 (mRNA)
NP_031854 (protein)

Location

Chr 19: 3.91 - 3.92 Mb

Chr 10: 80.59 - 80.6 Mb

Pubmed search

[1]

[2]

Death-associated protein kinase 3, also known as DAPK3, is a human gene.^[1]

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.^[1]

[edit] References

^ ^a ^b Entrez Gene: DAPK3 death-associated protein kinase 3.

[edit] Further reading

Kawai T, Matsumoto M, Takeda K, et al. (1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.". Mol. Cell. Biol. 18 (3): 1642–51. PMID 9488481.
Saito T, Seki N, Ohira M, et al. (1998). "Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization.". J. Hum. Genet. 43 (3): 209–11. PMID 9747039.
Murata-Hori M, Suizu F, Iwasaki T, et al. (1999). "ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells.". FEBS Lett. 451 (1): 81–4. PMID 10356987.
Page G, Lödige I, Kögel D, Scheidtmann KH (2000). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.". FEBS Lett. 462 (1-2): 187–91. PMID 10580117.
Page G, Kögel D, Rangnekar V, Scheidtmann KH (2000). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis.". Oncogene 18 (51): 7265–73. doi:10.1038/sj.onc.1203170. PMID 10602480.
Cariou B, Perdereau D, Cailliau K, et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta.". Mol. Cell. Biol. 22 (20): 6959–70. PMID 12242277.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Preuss U, Landsberg G, Scheidtmann KH (2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.". Nucleic Acids Res. 31 (3): 878–85. PMID 12560483.
Kawai T, Akira S, Reed JC (2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.". Mol. Cell. Biol. 23 (17): 6174–86. PMID 12917339.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Burch LR, Scott M, Pohler E, et al. (2004). "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.". J. Mol. Biol. 337 (1): 115–28. doi:10.1016/j.jmb.2003.10.081. PMID 15001356.
Endo A, Surks HK, Mochizuki S, et al. (2004). "Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase.". J. Biol. Chem. 279 (40): 42055–61. doi:10.1074/jbc.M403676200. PMID 15292222.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Schaaf CP, Benzing J, Schmitt T, et al. (2005). "Novel interaction partners of the TPR/MET tyrosine kinase.". FASEB J. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961.
Yu H, Jiang D, Guo Z, et al. (2005). "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.". Int. J. Androl. 28 (3): 163–70. doi:10.1111/j.1365-2605.2005.00522.x. PMID 15910542.
Takamoto N, Komatsu S, Komaba S, et al. (2007). "Novel ZIP kinase isoform lacks leucine zipper.". Arch. Biochem. Biophys. 456 (2): 194–203. doi:10.1016/j.abb.2006.09.026. PMID 17126281.