User:Dangoldy
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Daniel Larocque, PhD is a former postdoctoral researcher in Dr. Pedro Lowenstein and Maria Castro laboratory at the Board of Governors Gene Therapeutics Research Institute at Cedars-Sinai Medical Center, UCLA affiliated Hospital in Los Angeles.
Dr. Larocque was working on a project that characterizes the immune response against neurons and glial cells during brain inflammation. He is developing a specific transgenic approach to study the adaptive immune response in the brain. Moreover, Dr. Larocque has developed in vivo imaging techniques to investigate immune cell trafficking to the sites of CNS inflammation.
Studies are underway to characterize the immune response triggered by gene transfer using gene therapy vectors in the brain. This study has a goal of applying this knowledge to treatment of neuropathology such as multiple sclerosis, Parkinson's disease, brain cancer and others neuropathology.
Dr. Larocque received his bachelor's degree from the University of Sherbrooke and his master's degree in microbiology from the INRS-Institut Armand-Frappier in Laval, Canada. He earned his Doctoral degree in experimental medicine from McGill University (Montreal, Canada). His PhD study was on the characterization of QKI proteins in oligodendrocyte differentiation. The emphasis was on studying the role of this RNA binding protein in RNA trafficking and RNA stabilization in oligodendrocytes and Schwann cells. Those research have implication for diseases such Multiple Sclerosis, leukodystrophy, ALS, Parkinson and other neuropathology.
Dr. Larocque was a fellow from the Human Frontier Science Program, and previously was supported by the MS Society of Canada.
Daniel Larocque
daniel.larocque@mail.mcgill.ca
Recent Publications:
Daniel Larocque, Galarneau, A., Liu, H.N., Scott, M., Almazan, G., and Stephane Richard. (2005) p27KIP1 mRNA protection by QUAKING RNA binding proteins promote oligodendrocyte differentiation. Nature Neuroscience. 8: 27-33.
Larocque, D., Bergeron, J., Castro, M.G., Lowenstein, P.R. 2006. Gene Therapy of Multiple Sclerosis and CNS Autoimmune Mouse Models. Book Chapter, Taylor & Francis Publications. p.213-227. ISBN: 0824728475. http://www.amazon.com/Therapy-Neurological-Disorders-Pedro-Lowenstein/dp/0824728475
Larocque, D., Richard, S. 2005. QUAKING KH domain proteins as regulators of cell fate and myelination. RNA biology. 1 (3): 141-144.
Larocque, D., Bergeron, J., Castro, M.G., Lowenstein, P.R. 2006. Gene Therapy of Multiple Sclerosis and CNS Autoimmune Mouse Models. Book Chapter, Taylor & Francis Publications. p.213-227. ISBN: 0824728475
Lukong, K.E., Larocque, D., Tyner, A.L., Richard, S. 2005. Tyrosine phosphorylation of SAM68 by BRK regulates intranuclear localization and cell cycle progression. J Biol Chem. 280(46):38639-47.
Larocque, D., Pilotte, J., Chen, T., Cloutier, F., Couture, R., Massie, B., Pedrazza, L., Lasko, P., Almazan, G., Richard, S. 2002. Nuclear retention of MBP mRNAs in the quaking viable mice. Neuron 2002 Dec 5; 36(5):815-29.
Pilotte, J., Larocque, D., Richard, S. 2001. Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer. Genes & Development. 15(7):845-858.
