DAMGO
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| DAMGO | |
|---|---|
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| IUPAC name | (2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl) propanoyl]amino]propanoyl]amino]acetyl]-methylamino]- N-(2-hydroxyethyl)-3-phenylpropanamide |
| Other names | Ala2-MePhe4-Gly5-Enkephalin, DAGO, DAMGE |
| Identifiers | |
| CAS number | [78123-71-4] |
| PubChem | |
| SMILES | CC(C(=O)NCC(=O)N(C)C(CC1=CC=CC=C1)C (=O)NCCO)NC(=O)C(CC2=CC=C(C=C2)O)N |
| Properties | |
| Molecular formula | C26H35N5O6 |
| Molar mass | 513.59 g mol-1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin) is a synthetic opioid peptide with high μ-opioid receptor specificity. It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin.[1]
Its structure is H-Tyr-D-Ala-Gly-N-MePhe-Gly-OH.
[edit] References
- ^ Handa BK, Land AC, Lord JA, Morgan BA, Rance MJ, Smith CF. "Analogues of β-LPH61–64 possessing selective agonist activity at μ-opiate receptors." European Journal of Pharmacology. 1981 Apr 9;70(4):531-40. PMID 6263640. doi:10.1016/0014-2999(81)90364-2
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