DACH1

From Wikipedia, the free encyclopedia

Dachshund homolog 1 (Drosophila)

PDB rendering based on 1l8r.

Available structures: 1l8r

Identifiers

Symbol(s)

DACH1; DACH; FLJ10138

External IDs

OMIM: 603803 MGI: 1277991 HomoloGene: 7288

Gene ontology
Molecular Function:	• DNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004392 (mRNA)
NP_004383 (protein)

NM_001038610 (mRNA)
NP_001033699 (protein)

Location

Chr 13: 70.91 - 71.34 Mb

Chr 14: 96.71 - 97.05 Mb

Pubmed search

[1]

[2]

Dachshund homolog 1 (Drosophila), also known as DACH1, is a human gene.^[1]

This gene is similar to the Drosophila melanogaster dachshund gene, which encodes a nuclear factor essential for determining cell fates in the eye, leg, and nervous system of the fly. It is a member of the Ski gene family and is thought to be involved in eye development. Four alternatively spliced transcripts encoding different isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: DACH1 dachshund homolog 1 (Drosophila).

[edit] Further reading

Hammond KL, Hanson IM, Brown AG, et al. (2003). "Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb.". Mech. Dev. 74 (1-2): 121-31. PMID 9651501.
Hammond KL, Lettice LA, Hill RE, et al. (1999). "Human (DACH) and mouse (Dach) homologues of Drosophila dachshund map to chromosomes 13q22 and 14E3, respectively.". Genomics 55 (2): 252-3. doi:10.1006/geno.1998.5662. PMID 9933575.
Kozmik Z, Cvekl A (1999). "Localization of the human homologue of the Drosophila dachshund gene (DACH) to chromosome 13q21.". Genomics 59 (1): 110-1. doi:10.1006/geno.1999.5797. PMID 10395809.
Kozmik Z, Pfeffer P, Kralova J, et al. (1999). "Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene.". Dev. Genes Evol. 209 (9): 537-45. PMID 10502110.
Machon O, Backman M, Julin K, Krauss S (2001). "Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac.". Mech. Dev. 97 (1-2): 3-12. PMID 11025202.
Ayres JA, Shum L, Akarsu AN, et al. (2001). "DACH: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homologue.". Genomics 77 (1-2): 18-26. doi:10.1006/geno.2001.6618. PMID 11543628.
Ozaki H, Watanabe Y, Ikeda K, Kawakami K (2002). "Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins.". J. Hum. Genet. 47 (3): 107-16. PMID 11950062.
Kim SS, Zhang RG, Braunstein SE, et al. (2003). "Structure of the retinal determination protein Dachshund reveals a DNA binding motif.". Structure 10 (6): 787-95. PMID 12057194.
Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.". Mol. Cell. Biol. 22 (19): 6759-66. PMID 12215533.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wu K, Yang Y, Wang C, et al. (2004). "DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.". J. Biol. Chem. 278 (51): 51673-84. doi:10.1074/jbc.M310021200. PMID 14525983.
Nobrega MA, Ovcharenko I, Afzal V, Rubin EM (2003). "Scanning human gene deserts for long-range enhancers.". Science 302 (5644): 413. doi:10.1126/science.1088328. PMID 14563999.
Li X, Oghi KA, Zhang J, et al. (2003). "Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis.". Nature 426 (6964): 247-54. doi:10.1038/nature02083. PMID 14628042.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Martini SR, Davis RL (2005). "The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster.". J. Neurobiol. 64 (2): 133-44. doi:10.1002/neu.20130. PMID 15818552.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Wu K, Li A, Rao M, et al. (2006). "DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth.". Mol. Cell. Biol. 26 (19): 7116-29. doi:10.1128/MCB.00268-06. PMID 16980615.