DAB2IP

From Wikipedia, the free encyclopedia

DAB2 interacting protein

Identifiers

DAB2IP; AIP1; AF9Q34; DIP1/2; FLJ39072; KIAA1743

External IDs

OMIM: 609205 MGI: 1916851 HomoloGene: 13058

Gene ontology
Molecular Function:	• GTPase activator activity • protein binding
Cellular Component:	• intracellular • membrane
Biological Process:	• cell cycle • negative regulation of progression through cell cycle • regulation of small GTPase mediated signal transduction

Orthologs

Human

Mouse

Refseq

NM_032552 (mRNA)
NP_115941 (protein)

NM_001001602 (mRNA)
NP_001001602 (protein)

Location

Chr 9: 123.37 - 123.59 Mb

Chr 2: 35.4 - 35.55 Mb

Pubmed search

[1]

[2]

DAB2 interacting protein, also known as DAB2IP, is a human gene.^[1]

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: DAB2IP DAB2 interacting protein.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. PMID 11214970.
Wang Z, Tseng CP, Pong RC, et al. (2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
Chen H, Pong RC, Wang Z, Hsieh JT (2002). "Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization.". Genomics 79 (4): 573–81. doi:10.1006/geno.2002.6739. PMID 11944990.
Chen H, Toyooka S, Gazdar AF, Hsieh JT (2003). "Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines.". J. Biol. Chem. 278 (5): 3121–30. doi:10.1074/jbc.M208230200. PMID 12446720.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang R, He X, Liu W, et al. (2003). "AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3.". J. Clin. Invest. 111 (12): 1933–43. PMID 12813029.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
von Bergh AR, Wijers PM, Groot AJ, et al. (2004). "Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia.". Genes Chromosomes Cancer 39 (4): 324–34. doi:10.1002/gcc.20004. PMID 14978793.
Dote H, Toyooka S, Tsukuda K, et al. (2004). "Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer.". Clin. Cancer Res. 10 (6): 2082–9. PMID 15041729.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Zhang H, Zhang R, Luo Y, et al. (2004). "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.". J. Biol. Chem. 279 (43): 44955–65. doi:10.1074/jbc.M407617200. PMID 15310755.
Yano M, Toyooka S, Tsukuda K, et al. (2004). "Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers.". Int. J. Cancer 113 (1): 59–66. doi:10.1002/ijc.20531. PMID 15386433.
Chen H, Tu SW, Hsieh JT (2005). "Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer.". J. Biol. Chem. 280 (23): 22437–44. doi:10.1074/jbc.M501379200. PMID 15817459.
Kunze E, Von Bonin F, Werner C, et al. (2006). "Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements.". Int. J. Mol. Med. 17 (1): 3–13. PMID 16328005.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.