D-xylulose reductase

From Wikipedia, the free encyclopedia

In enzymology, a D-xylulose reductase (EC 1.1.1.9) is an enzyme that catalyzes the chemical reaction

xylitol + NAD⁺ $\rightleftharpoons$ D-xylulose + NADH + H⁺

Thus, the two substrates of this enzyme are xylitol and NAD⁺, whereas its 3 products are D-xylulose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is xylitol:NAD+ 2-oxidoreductase (D-xylulose-forming). Other names in common use include NAD+-dependent xylitol dehydrogenase, xylitol dehydrogenase, erythritol dehydrogenase, 2,3-cis-polyol(DPN) dehydrogenase (C3-5), pentitol-DPN dehydrogenase, and xylitol-2-dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1ZEM.

[edit] References

IUBMB entry for 1.1.1.9
BRENDA references for 1.1.1.9 (Recommended.)
PubMed references for 1.1.1.9
PubMed Central references for 1.1.1.9
Google Scholar references for 1.1.1.9
CHIANG C, KNIGHT SG (1960). "A new pathway of pentose metabolism". Biochem. Biophys. Res. Commun. 3: 554–9. doi:10.1016/0006-291X(60)90174-1. PMID 13692998.
Hickman J and Ashwell G (1959). "A sensitive and stereospecific enzymatic assay for xylulose". J. Biol. Chem. 234: 758–761.
JAKOBY WB, FREDERICKS J (1961). "Erythritol dehydrogenase from Aerobacter aerogenes". Biochim. Biophys. Acta. 48: 26–32. doi:10.1016/0006-3002(61)90511-X. PMID 13789254.