D-threo-aldose 1-dehydrogenase

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In enzymology, a D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) is an enzyme that catalyzes the chemical reaction

a D-threo-aldose + NAD⁺ $\rightleftharpoons$ a D-threo-aldono-1,5-lactone + NADH + H⁺

Thus, the two substrates of this enzyme are D-threo-aldose and NAD⁺, whereas its 3 products are D-threo-aldono-1,5-lactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-threo-aldose:NAD+ 1-oxidoreductase. Other names in common use include L-fucose dehydrogenase, (2S,3R)-aldose dehydrogenase, dehydrogenase, L-fucose, and L-fucose (D-arabinose) dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

[edit] References

IUBMB entry for 1.1.1.122
BRENDA references for 1.1.1.122 (Recommended.)
PubMed references for 1.1.1.122
PubMed Central references for 1.1.1.122
Google Scholar references for 1.1.1.122
Sasajima KI, Sinskey AJ (1979). "Oxidation of L-glucose by a Pseudomonad". Biochim. Biophys. Acta. 571: 120–6. PMID 40609.
Schachter H, Sarney J, McGuire EJ, Roseman S (1969). "Isolation of diphosphopyridine nucleotide-dependent L-fucose dehydrogenase from pork liver". J. Biol. Chem. 244: 4785–92. PMID 4309152.