D-nopaline dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a D-nopaline dehydrogenase (EC 1.5.1.19) is an enzyme that catalyzes the chemical reaction

N₂-(D-1,3-dicarboxypropyl)-L-arginine + NADP⁺ + H₂O L-arginine + 2-oxoglutarate + NADPH + H⁺

The 3 substrates of this enzyme are N2-(D-1,3-dicarboxypropyl)-L-arginine, NADP⁺, and H₂O, whereas its 4 products are L-arginine, 2-oxoglutarate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming). Other names in common use include D-nopaline synthase, nopaline dehydrogenase, nopaline synthase, NOS, 2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase, and (L-arginine-forming). This enzyme participates in arginine and proline metabolism.

[edit] References

• IUBMB entry for 1.5.1.19
• BRENDA references for 1.5.1.19 (Recommended.)
• PubMed references for 1.5.1.19
• PubMed Central references for 1.5.1.19
• Google Scholar references for 1.5.1.19
• Kemp JD, Sutton DW, Hack E (1979). "Purification and characterization of the crown gall specific enzyme nopaline synthase". Biochemistry. 18: 3755–60. PMID 476084. 

[edit] External links

The CAS registry number for this enzyme class is 64763-57-1.

• IUBMB entry for 1.5.1.19

• KEGG entry for 1.5.1.19

• BRENDA entry for 1.5.1.19

• NiceZyme view of 1.5.1.19

• EC2PDB: PDB structures for 1.5.1.19

• PRIAM entry for 1.5.1.19

• PUMA2 entry for 1.5.1.19

• IntEnz: Integrated Enzyme entry for 1.5.1.19

• MetaCyc entry for 1.5.1.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047829: D-nopaline dehydrogenase

• AMIGO entry for GO code 0047829: D-nopaline dehydrogenase