D-malate dehydrogenase (decarboxylating)

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In enzymology, a D-malate dehydrogenase (decarboxylating) (EC 1.1.1.83) is an enzyme that catalyzes the chemical reaction

(R)-malate + NAD⁺ pyruvate + CO₂ + NADH

Thus, the two substrates of this enzyme are (R)-malate and NAD⁺, whereas its 3 products are pyruvate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-malate:NAD+ oxidoreductase (decarboxylating). Other names in common use include D-malate dehydrogenase, D-malic enzyme, bifunctional L(+)-tartrate dehydrogenase-D(+)-malate, and (decarboxylating). This enzyme participates in butanoate metabolism.

[edit] References

• IUBMB entry for 1.1.1.83
• BRENDA references for 1.1.1.83 (Recommended.)
• PubMed references for 1.1.1.83
• PubMed Central references for 1.1.1.83
• Google Scholar references for 1.1.1.83
• Stern JR, O'Brien RW (1969). "Oxidation D-malic and beta-alkylmalic acids wild-type and mutant strains of Salmonella typhimurium and by Aerobacter aerogenes". J. Bacteriol. 98: 147–51. PMID 4889267. 

[edit] External links

The CAS registry number for this enzyme class is 37250-20-7.

• IUBMB entry for 1.1.1.83

• KEGG entry for 1.1.1.83

• BRENDA entry for 1.1.1.83

• NiceZyme view of 1.1.1.83

• EC2PDB: PDB structures for 1.1.1.83

• PRIAM entry for 1.1.1.83

• PUMA2 entry for 1.1.1.83

• IntEnz: Integrated Enzyme entry for 1.1.1.83

• MetaCyc entry for 1.1.1.83

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0046553: D-malate dehydrogenase (decarboxylating)

• AMIGO entry for GO code 0046553: D-malate dehydrogenase (decarboxylating)