D-lysopine dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a D-lysopine dehydrogenase (EC 1.5.1.16) is an enzyme that catalyzes the chemical reaction

N₂-(D-1-carboxyethyl)-L-lysine + NADP⁺ + H₂O L-lysine + pyruvate + NADPH + H⁺

The 3 substrates of this enzyme are N2-(D-1-carboxyethyl)-L-lysine, NADP⁺, and H₂O, whereas its 4 products are L-lysine, pyruvate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming). Other names in common use include D-lysopine synthase, lysopine dehydrogenase, D(+)-lysopine dehydrogenase, 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase, and (L-lysine-forming). This enzyme participates in lysine degradation.

[edit] References

• IUBMB entry for 1.5.1.16
• BRENDA references for 1.5.1.16 (Recommended.)
• PubMed references for 1.5.1.16
• PubMed Central references for 1.5.1.16
• Google Scholar references for 1.5.1.16
• Otten LA, Vreugdenhil D, Schilperoort RA (1977). "Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue". Biochim. Biophys. Acta. 485: 268–77. PMID 21695. 

[edit] External links

The CAS registry number for this enzyme class is 65187-41-9.

• IUBMB entry for 1.5.1.16

• KEGG entry for 1.5.1.16

• BRENDA entry for 1.5.1.16

• NiceZyme view of 1.5.1.16

• EC2PDB: PDB structures for 1.5.1.16

• PRIAM entry for 1.5.1.16

• PUMA2 entry for 1.5.1.16

• IntEnz: Integrated Enzyme entry for 1.5.1.16

• MetaCyc entry for 1.5.1.16

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047827: D-lysopine dehydrogenase

• AMIGO entry for GO code 0047827: D-lysopine dehydrogenase