D-lysine 5,6-aminomutase

From Wikipedia, the free encyclopedia

In enzymology, a D-lysine 5,6-aminomutase (EC 5.4.3.4) is an enzyme that catalyzes the chemical reaction

D-lysine 2,5-diaminohexanoate

Hence, this enzyme has one substrate, D-lysine, and one product, 2,5-diaminohexanoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is D-2,6-diaminohexanoate 5,6-aminomutase. Other names in common use include D-alpha-lysine mutase, and adenosylcobalamin-dependent D-lysine 5,6-aminomutase. This enzyme participates in lysine degradation. It employs one cofactor, cobamide.

[edit] References

• IUBMB entry for 5.4.3.4
• BRENDA references for 5.4.3.4 (Recommended.)
• PubMed references for 5.4.3.4
• PubMed Central references for 5.4.3.4
• Google Scholar references for 5.4.3.4
• Morley CG, Stadtman TC (1970). "Studies on the fermentation of D-alpha-lysine. Purification and properties of an adenosine triphosphate regulated B 12-coenzyme-dependent D-alpha-lysine mutase complex from Clostridium sticklandii". Biochemistry. 9: 4890–900. doi:10.1021/bi00827a010. PMID 5480154. 
• Stadtman TC, Tsai L (1967). "A cobamide coenzyme dependent migration of the epsilon-amino group of D-lysine". Biochem. Biophys. Res. Commun. 28: 920–6. doi:10.1016/0006-291X(67)90067-8. PMID 4229021. 

[edit] External links

The CAS registry number for this enzyme class is 9075-70-1.

• IUBMB entry for 5.4.3.4

• KEGG entry for 5.4.3.4

• BRENDA entry for 5.4.3.4

• NiceZyme view of 5.4.3.4

• EC2PDB: PDB structures for 5.4.3.4

• PRIAM entry for 5.4.3.4

• PUMA2 entry for 5.4.3.4

• IntEnz: Integrated Enzyme entry for 5.4.3.4

• MetaCyc entry for 5.4.3.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047826: D-lysine 5,6-aminomutase

• AMIGO entry for GO code 0047826: D-lysine 5,6-aminomutase