D-iditol 2-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a D-iditol 2-dehydrogenase (EC 1.1.1.15) is an enzyme that catalyzes the chemical reaction

D-iditol + NAD⁺ D-sorbose + NADH + H⁺

Thus, the two substrates of this enzyme are D-iditol and NAD⁺, whereas its 3 products are D-sorbose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-iditol:NAD+ 2-oxidoreductase. This enzyme is also called D-sorbitol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

[edit] References

• IUBMB entry for 1.1.1.15
• BRENDA references for 1.1.1.15 (Recommended.)
• PubMed references for 1.1.1.15
• PubMed Central references for 1.1.1.15
• Google Scholar references for 1.1.1.15
• Shaw DRD (1956). "Polyol dehydrogenases. 3. Galactitol dehydrogenase and D-iditol dehydrogenase". Biochem. J. 64: 394–405. 

[edit] External links

The CAS registry number for this enzyme class is 9028-22-2.

• IUBMB entry for 1.1.1.15

• KEGG entry for 1.1.1.15

• BRENDA entry for 1.1.1.15

• NiceZyme view of 1.1.1.15

• EC2PDB: PDB structures for 1.1.1.15

• PRIAM entry for 1.1.1.15

• PUMA2 entry for 1.1.1.15

• IntEnz: Integrated Enzyme entry for 1.1.1.15

• MetaCyc entry for 1.1.1.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047824: D-iditol 2-dehydrogenase

• AMIGO entry for GO code 0047824: D-iditol 2-dehydrogenase